In The Iliad, the Greek warrior Diomedes directly attacks and wounds both Aphrodite and Ares in a single day. He does so with the blessing of Athena, but the story makes it clear that it is Diomedes himself delivering the blows, not Athena on his behalf: divine assistance notwithstanding, this is direct human-on-god violence. And the blows, while not life-threatening, are serious enough to immediately drive both gods from the battlefield in distress to go seek healing on Olympus.
I’m sure that world mythologies are full of stories about humans fighting minor sprites and magical creatures, but Aphrodite and Ares are Olympians, the A-List deities of their pantheon.
Do any other mythologies depict their top-tier gods as vulnerable (even through the aid of other gods) to direct violence from mortal humans?